Green Synthesis of New Pyrrolo [1,2-a] quinoxalines as Antiproliferative Agents in GPER-expressing Breast Cancer Cells

4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biological properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER). In this work, synthesis and preliminary antiproliferative activity of a small set new 4,5-dihydropyrrolo[1,2-a]quinoxalines (18-20) pyrrolo[1,2-a]quinoxalines (21, 22) has been reported, inspired by known agents (G-1, G-15, G-36). The pyrroloquinoxalinic core was employed following Pictet–Spengler reaction, using surfactant p-dodecylbenzene sulphonic acid (p-DBSA), as catalyst. It demonstrated efficiency in catalysis 4-phenylpyrrole [1,2-a] quinoxaline type compound formation mild solvents such water, ethanol, hydroalcoholic solutions. addition, reactions proceeded short time (between 15 120 minutes) at room temperature high yields. vitro MTT assays showed that presence isopropyl groups furnished promising compounds. Although, acetyl group provided also effects, breaking down its responsibility GPER transactivation. Nevertheless, it is possible to conclude remain feasible scaffold develop against GPER-expressing cells.